| Date | Year | Opponent | Stadium | Location |
|---|---|---|---|---|
| Sept. 1 | 2012 | Miami Hurricanes* | Alumni Stadium | Chestnut Hill, MA |
| Sept. 8 | 2012 | Maine Black Bears | Alumni Stadium | Chestnut Hill, MA |
| Sept. 15 | 2012 | Northwestern Wildcats | Ryan Field | Evanston, IL |
| Sept. 29 | 2012 | Clemson Tigers* | Alumni Stadium | Chestnut Hill, MA |
| Oct. 6 | 2012 | Army Black Knights | Michie Stadium | West Point, N.Y. |
| Oct. 13 | 2012 | Florida St. Seminoles* | Doak Campbell Stadium | Tallahassee, FL |
| Oct. 20 | 2012 | Georgia Tech Yellow Jackets* | Bobby Dodd Stadium | Atlanta, GA |
| Oct. 27 | 2012 | Maryland Terrapins* | Alumni Stadium | Chestnut Hill, MA |
| Nov. 3 | 2012 | Wake Forest Demon Deacons* | BB&T Field at Groves Stadium | Winston-Salem, NC |
| Nov. 10 | 2012 | Notre Dame Fighting Irish | Alumni Stadium | Chestnut Hill, MA |
| Nov. 17 | 2012 | Virginia Tech Hokies* | Alumni Stadium | Chestnut Hill, MA |
| Nov. 24 | 2012 | N.C. State Wolfpack* | Carter-Finley Stadium | Raleigh, NC |
* Denotes ACC Game