The hits keep on coming for Boston College, who opens as a 21-point underdog this weekend at Clemson.

Clemson has played the Eagles the closest of any ACC Atlantic Division opponent during BC's six seasons in the conference, with an average margin of just 6.17 points over six games, with the latest game in the series a 16-10 win by BC. The Tigers have scored 125 points to BC's 114, but has won just two of the six meetings between the two schools as ACC divisional opponents. The all-time series is tied at 9-9-2.

Here are the last six lines and results from BC-Clemson games in the ACC.

2005: Boston College 16, Clemson 13 (BC +3)
2006: Boston College 34, Clemson 33 (BC +1)
2007: Boston College 20, Clemson 17 (BC +9)
2008: Clemson 27, Boston College 21 (CU +2.5)
2009: Clemson 25, Boston College 9 (CU -9)
2010: Boston College 16, Clemson 10 (BC +7)

Doesn't look like this one will be very close though, with the Tigers more than three touchdown favorites this weekend. If the Eagles have any hopes of retaining the leather helmet, they'll have to overcome a three TD point spread, a suddenly potent offense under first year OC Chad Morris, Tajh Boyd and a hostile Memorial Stadium environment. 

Other ACC lines of interest: Virginia Tech is a touchdown favorite at home over Miami, Georgia Tech is a 15-point favorite at home over Maryland and N.C. State is a 12.5 favorite over Central Michigan. There's currently no line on the Florida State-Wake Forest game as Vegas presumably waits to get an update on the status of QB E.J. Manuel.